Phospholipase A2 (PLA2G1B) Antibody – Rabbit Polyclonal

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

PLA2G1B: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.

Protein type: Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Lipid Metabolism - glycerophospholipid; Secreted; Phospholipase; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; EC 3.1.1.4; DNA replication

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; cell surface; extracellular region; secretory granule

Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; receptor binding

Biological Process: multicellular organismal lipid catabolic process; neutrophil chemotaxis; positive regulation of immune response; activation of MAPK activity; glycerophospholipid biosynthetic process; activation of phospholipase A2; neutrophil mediated immunity; actin filament organization; glucose transport; signal transduction; arachidonic acid secretion; activation of NF-kappaB transcription factor; phosphatidylcholine metabolic process; leukotriene biosynthetic process; positive regulation of fibroblast proliferation; defense response to Gram-positive bacterium; positive regulation of protein secretion; cellular response to insulin stimulus; innate immune response in mucosa; phospholipid metabolic process; antibacterial humoral response; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; fatty acid biosynthetic process; positive regulation of DNA replication; interleukin-8 production