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Auraptene Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750007

MBS5750007 is an inhibitor targeting Auraptene. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Auraptene, Inhibitor
Full Product Name
Auraptene
Form/Format
POWDER
Purity/Purification
99.2%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
298.4
CAS
495-02-3
Formula
C19H22O3
Pathways
Neuroscience
Target
BACE1
Smiles
CC(=CCC/C(=C/COc1cc2c(cc1)ccc(=O)o2)/C)C
Receptor
BACE1
Bioactivity
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit beta-secretase (BACE1) activity with an IC50 value of 345.1 muM.
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Structure of Auraptene, inhibitor

Auraptene Inhibitor – Cat# MBS5750007

Product References and Citations for Auraptene, inhibitor

1. Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21 (10), 1843-1850 (2000).

Other Notes

Small volumes of Auraptene, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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