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LYN-1604 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750013

MBS5750013 is an inhibitor targeting LYN-1604. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LYN-1604, Inhibitor
Full Product Name
LYN-1604
Product Gene Name
LYN-1604, inhibitor
Form/Format
POWDER
Purity/Purification
98.0%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
584.626 
CAS
2088939-99-3
Formula
C33H43Cl2N3O2
Pathways
Autophagy
Smiles
CC(C)CN(CC(=O)N1CCN(CC(c2ccc(Cl)cc2Cl)OCc2ccc3ccccc3c2)CC1)CC(C)C.Cl.Cl
Receptor
ULK1
Bioactivity
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells.
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product References and Citations for LYN-1604, inhibitor

1. Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu B. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1; 8 (4):2687-2701.

Other Notes

Small volumes of LYN-1604, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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