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AC-264613 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750049

MBS5750049 is an inhibitor targeting AC-264613. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AC-264613, Inhibitor
Full Product Name
AC-264613
Product Gene Name
AC-264613, inhibitor
Form/Format
POWDER
Purity/Purification
98.0%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
400.276
CAS
1051487-82-1
Formula
C19H18BrN3O2
Pathways
GPCR/G Protein
Smiles
CC(=NNC(=O)[C@@H]1[C@H](CNC1=O)c1ccccc1)c1cccc(Br)c1
Receptor
PAR-2
Bioactivity
AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca (2+) mobilization assays, with potencies ranging from 30 to 100 nM
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Structure of AC-264613, inhibitor

AC-264613 Inhibitor – Cat# MBS5750049

Product References and Citations for AC-264613, inhibitor

1. Cosimi E, et al. Stereoselective Synthesis of alpha-Fluoro-gamma-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2; 18 (23):6014-6017

Other Notes

Small volumes of AC-264613, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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