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SAR-20347 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750072

MBS5750072 is an inhibitor targeting SAR-20347. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SAR-20347, Inhibitor
Full Product Name
SAR-20347
Product Gene Name
SAR-20347, inhibitor
Form/Format
POWDER
Purity/Purification
98.0%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
444.847
CAS
1450881-55-6
Formula
C21H18ClFN4O4
Pathways
Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
Smiles
C1COCCN1C(=O)c1ccc(cc1)Nc1c(nc(o1)c1c(cccc1Cl)F)C(=O)N
Receptor
JAK1; JAK2; JAK3; TYK2
Bioactivity
SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively.
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for SAR-20347, inhibitor

Cancer

Product References and Citations for SAR-20347, inhibitor

1. Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1; 193 (7):3278-87.

Other Notes

Small volumes of SAR-20347, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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