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Autophinib Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750081

MBS5750081 is an inhibitor targeting Autophinib. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Autophinib, Inhibitor
Full Product Name
Autophinib
Form/Format
POWDER
Purity/Purification
99.4%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
346.731
CAS
1644443-47-9
Formula
C14H11ClN6O3
Pathways
Autophagy; PI3K/Akt/mTOR signaling
Target
starvation-induced autophagy; rapamycin-induced autophagy; VPS34
Smiles
Cc1cc(n[nH]1)Nc1cc(nc(n1)Oc1ccc(cc1)[N+](=O)[O-])Cl
Receptor
rapamycin-induced autophagy; starvation-induced autophagy; VPS34
Bioactivity
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product References and Citations for Autophinib, inhibitor

1. Robke L, et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3; 56 (28):8153-8157.

Other Notes

Small volumes of Autophinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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