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SPI 112 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750110

MBS5750110 is an inhibitor targeting SPI 112. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SPI 112, Inhibitor
Full Product Name
SPI 112
Product Gene Name
SPI 112, inhibitor
Form/Format
POWDER
Purity/Purification
99.5%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
468.45
CAS
1051387-90-6
Formula
C22H17FN4O5S
Smiles
OC(=O)c1cccc(N\N=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)cc2)c1
Receptor
SHP-2
Bioactivity
SPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Structure of SPI 112, inhibitor

SPI 112 Inhibitor – Cat# MBS5750110

Product References and Citations for SPI 112, inhibitor

1. Chen L, et al. Biochem Pharmacol. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. 2010 Sep 15; 80 (6):801-10

Other Notes

Small volumes of SPI 112, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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