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JK-P3 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750114

MBS5750114 is an inhibitor targeting JK-P3. More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JK-P3, Inhibitor
Full Product Name
JK-P3
Product Gene Name
JK-P3, inhibitor
Form/Format
POWDER
Purity/Purification
99.5%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
323.35
CAS
942655-44-9
Formula
C18H17N3O3
Pathways
Angiogenesis; Tyrosine Kinase/Adaptors
Target
VEGFR-2
Smiles
COc1c(cc(cc1)C(=O)Nc1n[nH]c(c1)c1ccccc1)OC
Receptor
VEGFR2
Bioactivity
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 muM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product References and Citations for JK-P3, inhibitor

1. Antony M. Latham, et al. Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. VEGF Signaling pp 121-131

Other Notes

Small volumes of JK-P3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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