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17-AAG Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750131

MBS5750131 is an inhibitor targeting 17-AAG. Also known as 17-AAG (Tanespimycin). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
17-AAG, Inhibitor
Full Product Name
17-AAG (Tanespimycin)
Product Gene Name
17-AAG, inhibitor
Form/Format
POWDER
Purity/Purification
99.83%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
585.69
CAS
75747-14-7
Formula
C31H43N3O8
Pathways
Cytoskeletal Signaling; Metabolism
Target
HSP90
Smiles
CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
Receptor
HSP90
Bioactivity
17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Solubility
DMSO: 100mg/ml (170.74 mM); Water: <1mg/ml; Ethanol: 5mg/ml (8.54 mM)
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for 17-AAG, inhibitor

Cancer

Structure of 17-AAG, inhibitor

17-AAG Inhibitor – Cat# MBS5750131

Product References and Citations for 17-AAG, inhibitor

1. Kamal A, et al. Nature, 2003, 425 (6956), 407-410.

Other Notes

Small volumes of 17-AAG, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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