Flavokawain A Inhibitor

1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model, prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. 2. Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-kappaB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

Small volumes of Flavokawain A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5750317 is an inhibitor targeting Flavokawain A.