Capmatinib 2HCl Inhibitor

Name: Capmatinib 2HCl Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750411
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750411

INCB-28060(free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Capmatinib 2HCl, Inhibitor

Full Product Name

Capmatinib 2HCl

Product Synonym Names

c-Met/HGFR

Form/Format

POWDER

Purity/Purification

99.8%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

485.34

CAS Number

1197376-85-4

Formula

C23H19Cl2FN6O

Smiles

Cl.Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

Solubility

DMSO: 2 mg/mL (4.84 mM)

Pathways

Tyrosine Kinase; Adaptors

Receptor

c-Met

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for Capmatinib 2HCl, inhibitor

Cancer

Product References and Citations for Capmatinib 2HCl, inhibitor

1. Liu X, et al,A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res, 2011, 17(227). 7127-7138.

Other Notes

Small volumes of Capmatinib 2HCl, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Capmatinib 2HCl purchase

MBS5750411 is an inhibitor targeting Capmatinib 2HCl.