THZ531 Inhibitor

Name: THZ531 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750438
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750438

THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

THZ531, Inhibitor

Full Product Name

THZ531

Product Gene Name

THZ531, inhibitor

Product Synonym Names

CDK

Form/Format

POWDER

Purity/Purification

99.9%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

558.08

CAS Number

1702809-17-3

Formula

C30H32ClN7O2

Smiles

O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C=C1)/C=C/CN(C)C

Solubility

DMSO: Soluble

Pathways

Cell Cycle; Checkpoint

Receptor

CDK12,CDK13

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for THZ531, inhibitor

Cancer

Product References and Citations for THZ531, inhibitor

1. Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 Oct; 12(10):876-84.

Other Notes

Small volumes of THZ531, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THZ531 purchase

MBS5750438 is an inhibitor targeting THZ531.