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(R)-GNE-140 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750439

(R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
(R)-GNE-140, Inhibitor
Full Product Name
(R)-GNE-140
Product Synonym Names
Dehydrogenase
Form/Format
POWDER
Purity/Purification
95.5%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
499.04
CAS Number
2003234-63-5
Formula
C25H23ClN2O3S2
Smiles
OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1cccs1)c1ccc(cc1)N1CCOCC1
Solubility
DMSO: Soluble
Pathways
Metabolism
Receptor
LDH
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of (R)-GNE-140, inhibitor

(R)-GNE-140 Inhibitor – Cat# MBS5750439

Product References and Citations for (R)-GNE-140, inhibitor

1. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26; 7(10):896-901.

Other Notes

Small volumes of (R)-GNE-140, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (R)-GNE-140 purchase

MBS5750439 is an inhibitor targeting (R)-GNE-140.
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