KI20227 Inhibitor

Name: KI20227 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750456
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750456

Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRbeta(IC50: 451/217 nM), respectively. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ki20227, Inhibitor

Full Product Name

Ki20227

Product Gene Name

Ki20227, inhibitor

Product Synonym Names

CSF-1R; VEGFR

Form/Format

POWDER

Purity/Purification

99.4%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

480.54

CAS Number

623142-96-1

Formula

C24H24N4O5S

Smiles

CC(C1=NC=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC

Solubility

DMSO: 7.2 mg/mL

Pathways

Tyrosine Kinase; Adaptors

Receptor

CSF-1R, VEGFR2

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for Ki20227, inhibitor

Cancer

Product References and Citations for Ki20227, inhibitor

1. Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov; 5(11):2634-43.

Other Notes

Small volumes of Ki20227, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ki20227 purchase

MBS5750456 is an inhibitor targeting Ki20227.