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ACTB-1003 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750458

MBS5750458 is an inhibitor targeting ACTB-1003. ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2). More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACTB-1003, Inhibitor
Full Product Name
ACTB-1003
Product Gene Name
ACTB-1003, inhibitor
Product Synonym Names
FGFR; VEGFR; Tie-2
Form/Format
POWDER
Purity/Purification
99.3%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
591.54
CAS Number
939805-30-8
Formula
C27H26F5N7O3
Smiles
COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5
Solubility
DMSO: >=35 mg/mL
Pathways
Tyrosine Kinase; Adaptors;
Receptor
FGFR1,VEGFR2,Tie-2
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for ACTB-1003, inhibitor

Cancer

Chemical Structure of ACTB-1003, inhibitor

ACTB-1003 Inhibitor – Cat# MBS5750458

Product References and Citations for ACTB-1003, inhibitor

1. Patel K, et al. ACTB-1003: An oral kinase inhibitor targeting cancer mutations (FGFR), angiogenesis (VEGFR2, TEK), and induction of apoptosis (RSK and p70S6K). Journal of Clinicalal Oncology 28, no. 15 DOI: 10.1200/jco.2010.28.15_suppl.e13665

Other Notes

Small volumes of ACTB-1003, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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