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Tropifexor Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750507

MBS5750507 is an inhibitor targeting Tropifexor. Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tropifexor, Inhibitor
Full Product Name
Tropifexor
Product Synonym Names
FXR agonist
Form/Format
POWDER
Purity/Purification
99.30%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
603.58
CAS Number
1383816-29-2
Formula
C29H25F4N3O5S
Smiles
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C(C(O)=O)C=C7S6)[C@H](CC5)C4
Solubility
DMSO: >=80.66 mg/mL
Pathways
Metabolism
Receptor
FXR
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for Tropifexor, inhibitor

Digestive Disease (Hepatobiliary Disease)

Chemical Structure of Tropifexor, inhibitor

Tropifexor Inhibitor – Cat# MBS5750507

Product References and Citations for Tropifexor, inhibitor

1. Tully DC,etal.Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).J Med Chem. 2017 Dec 28; 60(24):9960-9973.

Other Notes

Small volumes of Tropifexor, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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