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Ac-CoA Synthase Inhibitor1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750508

ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ac-CoA Synthase Inhibitor1, Inhibitor
Full Product Name
Ac-CoA Synthase Inhibitor1
Product Synonym Names
Fatty Acid Synthase inhibitor; Histone Acetylation inhibitor
Form/Format
POWDER
Purity/Purification
99.8%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
410.51
CAS Number
508186-14-9
Formula
C20H18N4O2S2
Smiles
COCCNC(=O)Nc2cc3nc(c1cccs1)c(nc3cc2)c4cccs4
Solubility
DMSO: 28 mg/mL (68.2 mM)
Ethanol: 2 mg/mL (4.87 mM)
Water: <1 mg/mL
(<1 mg/mL refers to the product slightly soluble or insoluble)
Receptor (IC50)
ACSS2
In vitro Activity
This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 = 6.8 uM. The quinoxaline is also able to inhibit HepG2 utilization of [14C]acetate for histone acetylation with IC50 = 5.5 uM

Chemical Structure of Ac-CoA Synthase Inhibitor1, inhibitor

Ac-CoA Synthase Inhibitor1 Inhibitor – Cat# MBS5750508

Product References and Citations for Ac-CoA Synthase Inhibitor1, inhibitor

1. Comerford SA,etal.Acetate dependence of tumors.Cell. 2014 Dec 18; 159(7):1591-602.

Other Notes

Small volumes of Ac-CoA Synthase Inhibitor1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ac-CoA Synthase Inhibitor1 purchase

MBS5750508 is an inhibitor targeting Ac-CoA Synthase Inhibitor1.
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