• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ML221 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750517

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 uM in the cAMP assay, and 1.75 uM in the beta-arrestin assay, and EC80 of 10 nM in both assays. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ML221, Inhibitor
Full Product Name
ML221
Product Gene Name
ML221, inhibitor
Product Synonym Names
Apelin receptor antagonist
Form/Format
POWDER
Purity/Purification
97.7%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
385.35
CAS Number
877636-42-5
Formula
C17H11N3O6S
Smiles
C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
Solubility
DMSO: >31 mg/mL
Pathways
GPCR; G Protein
Receptor
APJ
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of ML221, inhibitor

ML221 Inhibitor – Cat# MBS5750517

Product References and Citations for ML221, inhibitor

1. Maloney PR, etal. Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 2012 Nov 1; 22(21):6656-60.

Other Notes

Small volumes of ML221, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ML221 purchase

MBS5750517 is an inhibitor targeting ML221.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000