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MS049 2HCl Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750519

MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 uM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MS049 2HCl, Inhibitor
Full Product Name
MS049 2HCl (1502816-23-0(Free Base))
Product Synonym Names
Histone Methyltransferase inhibitor
Form/Format
POWDER
Purity/Purification
99.9%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
321.28
CAS Number
1502816-23-0 (Free Base)
Formula
C15H26Cl2N2O
Smiles
Cl.Cl.CNCCN1CCC(CC1)OCc2ccccc2
Solubility
DMSO: 30 mg/mL; Ethanol: 30 mg/ml; PBS(pH7.2): 10 mg/ml
Pathways
Chromatin; Epigenetic
Receptor
PRMT4; PRMT6
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of MS049 2HCl, inhibitor

MS049 2HCl Inhibitor – Cat# MBS5750519

Product References and Citations for MS049 2HCl, inhibitor

1. Shen Y, etal. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6[J]. Journal of Medicinal Chemistry, 2016, 59(19):9124-9139.

Other Notes

Small volumes of MS049 2HCl, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MS049 2HCl purchase

MBS5750519 is an inhibitor targeting MS049 2HCl. Also known as MS049 2HCl (1502816-23-0(Free Base)).
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