PF-06409577 Inhibitor

Name: PF-06409577 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750544
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750544

PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for alpha1beta1gamma1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PF-06409577, Inhibitor

Full Product Name

PF-06409577

Product Gene Name

PF-06409577, inhibitor

Product Synonym Names

AMPK

Form/Format

POWDER

Purity/Purification

98.0%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

341.79

CAS Number

1467057-23-3

Formula

C19H16ClNO3

Smiles

OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1

Solubility

DMSO: 100 mM; Ethanol: 20 mM; Water: Insoluble

Pathways

PI3K; Akt; mTOR Signaling

Receptor

AMPK alpha1beta1gamma1

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for PF-06409577, inhibitor

Diabetes

Product References and Citations for PF-06409577, inhibitor

1. Cameron K O, Kung D W, Kalgutkar A S, et al. Discovery and preClinicalal characterization of 6-chloro-5-[4-(1-hydroxycyclobutyl) phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577), a direct activator of adenosine monophosphate-activated protein kinase (AMPK), for the potential treatment of diabetic nephropathy[J]. Journal of medicinal chemistry, 2016, 59(17): 8068-8081.

Other Notes

Small volumes of PF-06409577, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06409577 purchase

MBS5750544 is an inhibitor targeting PF-06409577.