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A-674563 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750558

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
A-674563, Inhibitor
Full Product Name
A-674563 HCl (552325-73-2(Free Base))
Product Gene Name
A-674563, inhibitor
Product Synonym Names
Akt; CDK; PKA
Form/Format
POWDER
Purity/Purification
98.0%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
394.9
CAS Number
552325-73-2 (Free Base)
Formula
C22H23ClN4O
Smiles
Cl.Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1
Solubility
DMSO: >30 mg/mL
Pathways
PI3K; Akt; mTOR Signaling; Cell Cycle; Checkpoint; GPCR; G Protein
Receptor
Akt1; CDK2; PKA
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of A-674563, inhibitor

A-674563 Inhibitor – Cat# MBS5750558

Product References and Citations for A-674563, inhibitor

1. Luo Y, Shoemaker A R, Liu X, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.[J]. Molecular Cancer Therapeutics, 2005, 4(6):977.

Other Notes

Small volumes of A-674563, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A-674563 purchase

MBS5750558 is an inhibitor targeting A-674563. Also known as A-674563 HCl (552325-73-2(Free Base)).
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