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GSK-25 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750590

GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GSK-25, Inhibitor
Full Product Name
GSK-25
Product Gene Name
GSK-25, inhibitor
Product Synonym Names
S6 Kinase inhibitor; mTOR inhibitor
Form/Format
POWDER
Purity/Purification
98.00%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
513.34
CAS Number
874119-56-9
Formula
C24H16Cl2F2N6O
Smiles
CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F
Solubility
DMSO: Soluble
Pathways
PI3K; Akt; mTOR Signaling; PI3K; Akt; mTOR Signaling
Receptor
RSK1; mTOR (p70S6K)
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of GSK-25, inhibitor

GSK-25 Inhibitor – Cat# MBS5750590

Product References and Citations for GSK-25, inhibitor

1. Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases [J]. J Med Chem. 2008 Nov 13; 51(21):6631-4.

Other Notes

Small volumes of GSK-25, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-25 purchase

MBS5750590 is an inhibitor targeting GSK-25.
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