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L189 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750614

MBS5750614 is an inhibitor targeting L189. L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 uM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L189, Inhibitor
Full Product Name
L189
Product Gene Name
L189, inhibitor
Product Synonym Names
DNA/RNA Synthesis inhibitor
Form/Format
POWDER
Purity/Purification
98.00%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
246.29
CAS Number
64232-83-3
Formula
C11H10N4OS
Smiles
Nc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1
Solubility
DMSO: 25 mg/mL; Ethanol: 1 mg/mL; Water: Insoluble
Pathways
DNA Damage; DNA Repair
Receptor
DNA Ligase I; DNA Ligase III; DNA Ligase IV
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of L189, inhibitor

L189 Inhibitor – Cat# MBS5750614

Product References and Citations for L189, inhibitor

1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008

Other Notes

Small volumes of L189, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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