YHO-13177 Inhibitor

Name: YHO-13177 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750680
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750680

YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

YHO-13177, Inhibitor

Full Product Name

YHO-13177

Product Gene Name

YHO-13177, inhibitor

Product Synonym Names

BCRP

Form/Format

POWDER

Purity/Purification

98.00%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

370.47

CAS Number

912287-56-0

Formula

C20H22N2O3S

Smiles

COc1ccc(cc1OC)C(\C#N)=C\c2ccc(s2)N3CCC(O)CC3

Solubility

DMSO: 10 mM

Pathways

Membrane Transporter; Ion Channel

Receptor

BCRP

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for YHO-13177, inhibitor

Cancer

Product References and Citations for YHO-13177, inhibitor

1. Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul; 10(7):1252-63.

Other Notes

Small volumes of YHO-13177, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YHO-13177 purchase

MBS5750680 is an inhibitor targeting YHO-13177.