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Simeprevir Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750754

Simeprevir is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Simeprevir, Inhibitor
Full Product Name
Simeprevir
Product Synonym Names
HCV Protease
Form/Format
POWDER
Purity/Purification
98.00%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
749.94
CAS Number
923604-59-5
Formula
C28H47N5O7S2
Smiles
COc1ccc2c(O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(C)CCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(=O)NS(=O)(=O)C3CC3)cc(nc2c1C)-c1nc(cs1)C(C)C
Solubility
DMSO: 30 mg/mL; Water: Insoluble
Pathways
Microbiology & Virology
Receptor
HCV NS3/4A protease; HCV
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of Simeprevir, inhibitor

Simeprevir Inhibitor – Cat# MBS5750754

Product References and Citations for Simeprevir, inhibitor

1. Lin TI, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.Antimicrob Agents Chemother. 2009 Apr; 53(4):1377-85. Epub 2009 Jan 26.

Other Notes

Small volumes of Simeprevir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Simeprevir purchase

MBS5750754 is an inhibitor targeting Simeprevir.
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