Ro 5-3335 Inhibitor

Name: Ro 5-3335 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5750755
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750755

Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 uM). It represses RUNX1/CBFbeta-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ro 5-3335, Inhibitor

Full Product Name

Ro 5-3335

Product Synonym Names

DNA/RNA Synthesis

Form/Format

POWDER

Purity/Purification

98.00%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

259.69

CAS Number

30195-30-3

Formula

C13H10ClN3O

Smiles

Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1

Solubility

DMSO: 100 mM

Pathways

DNA Damage; DNA Repair

Receptor

CBFbeta-Runx1

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for Ro 5-3335, inhibitor

Anti-infection

Product References and Citations for Ro 5-3335, inhibitor

1. Cunningham L, et al.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction.Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14592-7.

Other Notes

Small volumes of Ro 5-3335, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ro 5-3335 purchase

MBS5750755 is an inhibitor targeting Ro 5-3335.