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ABBV-744 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750765

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ABBV-744, Inhibitor
Full Product Name
ABBV-744
Product Gene Name
ABBV-744, inhibitor
Product Synonym Names
Epigenetic Reader Domain
Form/Format
POWDER
Purity/Purification
98.00%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
491.55
CAS Number
2138861-99-9
Formula
C28H30FN3O4
Smiles
CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1C)C(C)(C)O
Solubility
DMSO: 10 mM
Pathways
Chromatin; Epigenetic
Receptor
BET bromodomain
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of ABBV-744, inhibitor

ABBV-744 Inhibitor – Cat# MBS5750765

Product References and Citations for ABBV-744, inhibitor

Emily J. Faivre, et al. First-in-class, highly BDII-selective BET family inhibitor ABBV-744 displays potent anti-tumor activity in androgen receptor positive prostate cancer models and an improved tolerability profile. Cancer Res. 2018, 78(13 Suppl):Abstract nr 4960.

Other Notes

Small volumes of ABBV-744, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABBV-744 purchase

MBS5750765 is an inhibitor targeting ABBV-744.
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