7-Acetoxy-4-methylcoumarin Inhibitor

7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media, a cell membrane environmental mimic, to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin, the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum.

1. Berman HA,et al.Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase.Mol Pharmacol. 1992 Feb; 41(2):412-8.

Small volumes of 7-Acetoxy-4-methylcoumarin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751060 is an inhibitor targeting 7-Acetoxy-4-methylcoumarin.