CCT245737 Inhibitor

Name: CCT245737 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751082
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751082

CCT245737 is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCT245737, Inhibitor

Full Product Name

CCT245737

Product Gene Name

CCT245737, inhibitor

Product Synonym Names

Chk inhibitor

Form/Format

POWDER

Purity/Purification

98.00%

Preparation and Storage

Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C

Molecular Weight

379.34

CAS Number

1489389-18-5

Formula

C16H16F3N7O

Smiles

FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1

Solubility

DMSO: 50 mg/mL; Ethanol: 5 mg/mL; Water: Insoluble

Pathways

Cell Cycle; Checkpoint

Receptor

Chk1

Product Remark

For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product Categories/Family for CCT245737, inhibitor

Cancer

Product References and Citations for CCT245737, inhibitor

1. Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinicalal Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J Med Chem. 2016 Jun 9; 59(11):5221-37.

Other Notes

Small volumes of CCT245737, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT245737 purchase

MBS5751082 is an inhibitor targeting CCT245737.