Gigantol Inhibitor

Gigantol is a novel inhibitor of the Wnt/beta-catenin pathway. It inhibits Wnt/beta-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic beta-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-kappaB signaling pathway.Gigantol also shows alpha-glucosidase inhibitory activity.

1. Yu S, et al. Gigantol inhibits Wnt/beta-catenin signaling and exhibits anticancer activity in breast cancer cells:[J]. Bmc Complementary & Alternative Medicine, 2018, 18(1):59.

Small volumes of Gigantol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751146 is an inhibitor targeting Gigantol.