dBET1 Inhibitor

Name: dBET1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751212
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751212

dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430nM) and induces apoptosis. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

dBET1, Inhibitor

Full Product Name

dBET1

Product Gene Name

dBET1, inhibitor

Form/Format

Powder

Purity/Purification

99.30%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

785.27

Formula

C38H37ClN8O7S

CAS

1799711-21-9

Smiles

Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1

Receptor (IC50)

BET: 430nM (EC50)

Solubility

DMSO: 50mg/mL
Water: Insoluble
Ethanol: 5mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for dBET1, inhibitor

Home; Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for dBET1, inhibitor

1. Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348 (6241):1376-81.

Other Notes

Small volumes of dBET1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for dBET1 purchase

MBS5751212 is an inhibitor targeting dBET1.