Glyceryl trimyristate Inhibitor

Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ranging from yeast to humans. In humans, glyceryl trimyristate is involved in the metabolic disorder called de novo triacylglycerol biosynthesis glyceryl trimyristate pathway.

1. Pynn C J, Picardi M V, Nicholson T, et al. Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment.[J]. Ajp Regulatory Integrative & Comparative Physiology, 2010, 299 (5):R1306-16.
2. Legrand P, Beauchamp E, Catheline D, et al. Short Chain Saturated Fatty Acids Decrease Circulating Cholesterol and Increase Tissue PUFA Content in the Rat[J]. Lipids, 2010, 45 (11):975-1986.
3. Lesot P, Serhan Z, Aroulanda C, et al. Analytical contribution of NAD 2D-NMR spectroscopy in polypeptide mesophases to the investigation of triglycerides[J]. Magnetic Resonance in Chemistry, 2012, 50 (S1):S2-S11.

Small volumes of Glyceryl trimyristate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751331 is an inhibitor targeting Glyceryl trimyristate.