Erucic acid Inhibitor

Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239). Erucic acid is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.

1. Aubourg P, Adamsbaum C, Lavallardrousseau M C, et al. A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy.[J]. New England Journal of Medicine, 1993, 329 (11):745.
2. Brown D G, Rao S, Weir T L, et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool[J]. Cancer & Metabolism, 2016, 4 (1):11.
3. Dercksen M, Kulik W, Mienie L J, et al. Polyunsaturated fatty acid status in treated isovaleric acidemia patients[J]. European Journal of Clinical Nutrition, 2016, 70 (10).
4. Bu B, Ashwood P, Harvey D, et al. Fatty acid compositions of red blood cell phospholipids in children with autism[J]. Prostagrandins Leukot Essent Fatty Acids, 2006, 74 (4):215-221.
5. Rizzo W B, Leshner R T, Odone A, et al. Dietary erucic acid therapy for X?linked adrenoleukodystrophy[J]. Neurology, 1989, 39 (11):1415-1422.
6. Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90.

Small volumes of Erucic acid, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751345 is an inhibitor targeting Erucic acid.