(+/-)-Methyl Jasmonate Inhibitor

(+/-)-Jasmonic acid methyl ester induces the synthesis of proteinase inhibitors in plant leaves. In cancer cells, it suppresses proliferation and induces apoptosis. More specifically, methyl jasmonate inhibits hexokinase that is bound to mitochondria. As hexokinase is overexpressed in cancer cells and contributes to cancer cell growth and survival, methyl jasmonate's disruption of mitochondrial hexokinase activity selectively targets, and kills, cancer cells. (+/-)-Jasmonic acid methyl ester derivatives also have potential as anti-inflammatory agents. Methyl jasmonate has been primarily detected in urine.

1. Farmer, E.E., and Ryan, C.A. Interplant communication: Airborne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves. Proc Natl Acad Sci U S A. 1990 Oct;87 (19):7713-6.
2. Fingrut, O., and Flescher, E. Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells. Leukemia 16, 608-616 (2002).
3. Goldin, N., et al. Methyl jasmonate binds to and detaches mitochondria-bound hexokinase. Oncogene 27, 4636-4643 (2008).

Small volumes of (+/-)-Methyl Jasmonate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751377 is an inhibitor targeting (+/-)-Methyl Jasmonate.