1-Oleoyl-rac-glycerol Inhibitor

1-O-Oleyl-rac-glycerol, also known as monoolein, is a surfactant that releases free glycerol and oleic acid upon hydrolysis. Monoolein has been used in liquid crystal studies and research shows that in the presence of monoolein, the penetration of the drug cisplatin (sc-200896) is doubled.

1. Caboi F, Amico G S, Pitzalis P, et al. Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior[J]. Chemistry and Physics of Lipids, 2001, 109 (1):47-62.
2. Simonetti L D D, Gelfuso G M, Barbosa J C R, et al. Assessment of the percutaneous penetration of cisplatin: The effect of monoolein and the drug skin penetration pathway[J]. European Journal of Pharmaceutics & Biopharmaceutics, 2009, 73 (1):0-94.
3. Pichot R, Spyropoulos F, Norton I T. Mixed-emulsifier stabilised emulsions: Investigation of the effect of monoolein and hydrophilic silica particle mixtures on the stability against coalescence[J]. Journal of Colloid and Interface Science, 2009, 329 (2):284-291.

Small volumes of 1-Oleoyl-rac-glycerol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751413 is an inhibitor targeting 1-Oleoyl-rac-glycerol.