Alkannin Inhibitor

Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-kappaB-mediated pathway.

1. Takano-Ohmuro H, Yoshida L S, Yuda Y, et al. Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity[J]. Inflammation Research, 2008, 57 (10):484-488.
2. Liu J P, Liu D, Gu J F, et al. Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC?803 via the Toll?like receptor 2/nuclear factor?kappa B pathway[J]. Journal of Pharmacy & Pharmacology, 2015, 67 (8):1143-1155.
3. Gara R K, Srivastava V K, Duggal S, et al. Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway[J]. Journal of Biomedical Science, 2015, 22 (1):26.
4. Qu D, Xu X, Zhang M, et al. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Molecular Medicine Reports, 2015.

Small volumes of Alkannin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751427 is an inhibitor targeting Alkannin.