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NPS-2143 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751434

MBS5751434 is an inhibitor targeting NPS-2143. Also known as NPS-2143 HCL. NPS-2143 is a selective potent calcium ion-sensing receptor antagonist. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NPS-2143, Inhibitor
Full Product Name
NPS-2143 HCL
Product Gene Name
Product Synonym Names
NPS-2143 hydrochloride
Form/Format
Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
445.38
Formula
C24H25ClN2O2.HCl
CAS
324523-20-8
Smiles
Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
Receptor (IC50)
CaSR
Solubility
DMSO: 10mM
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for NPS-2143, inhibitor

Structure of NPS-2143, inhibitor

NPS-2143 Inhibitor – Cat# MBS5751434

Product References and Citations for NPS-2143, inhibitor

1. Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52 (21), 6599-6605.
2. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, PohlnM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111 (4):469-81. Epub 2012 Jun 22.
3. Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153 (3):1232-41. Epub 2011 Dec 30.
4. Huang Y, Breitwieser GE. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J Biol Chem. 2007 Mar 30;282 (13):9517-25
5. Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56 (5):753-60.

Other Notes

Small volumes of NPS-2143, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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