Guanosine 5'-triphosphate trisodium salt Inhibitor

Guanosine 5'-triphosphate trisodium salt activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades.Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

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2. Dhanasekaran N, Tsim S T, Dermott J M, et al. Regulation of cell proliferation by G proteins[J]. ONCOGENE, 1998, 17 (11):1383-1394.
3. J Gómez, C Martínez-A, A González, et al. Dual role of Ras and Rho proteins: at the cutting edge of life and death[J]. Immunology and Cell Biology, 1998, 76 (2):125-134.

Small volumes of Guanosine 5'-triphosphate trisodium salt, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751436 is an inhibitor targeting Guanosine 5'-triphosphate trisodium salt.