SSR240612 Inhibitor

Name: SSR240612 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751512
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751512

SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 and 358-481nM for B1 and B2 receptors, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SSR240612, Inhibitor

Full Product Name

SSR240612

Product Gene Name

SSR240612, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

793.41

Formula

C42H53ClN4O7S

CAS

464930-42-5

Smiles

Cl.COc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H](CC(=O)N[C@H](Cc1ccc(CN2[C@@H](C)CCC[C@H]2C)cc1)C(=O)N(C)C(C)C)c1ccc2OCOc2c1

Receptor (IC50)

B1 Human MRC5: 0.48nM (Ki)
B1 Human HEK-B1: 0.73nM (Ki)
B2 Human CHO-B2: 358nM (Ki)

Solubility

DMSO: 100mg/mL, 126mM
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for SSR240612, inhibitor

Home; GPCR/G Protein; Bradykinin Receptor

Product References and Citations for SSR240612, inhibitor

1. Gougat J, et al. SSR240612 [ (2R)-2-[ ((3R)-3- (1,3-benzodioxol-5-yl)-3-[[ (6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3- (4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2004 May;309 (2):661-9.
2. Rodrigues-Junior VS, et al. Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice. Tuberculosis (Edinb). 2018 Mar;109:1-7.
3. Dias JP, et al. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Br J Pharmacol. 2007 Sep;152 (2):280-7.

Other Notes

Small volumes of SSR240612, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SSR240612 purchase

MBS5751512 is an inhibitor targeting SSR240612.