FM381 Inhibitor

Name: FM381 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751553
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751553

FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FM381, Inhibitor

Full Product Name

FM381

Product Gene Name

FM381, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

428.49

Formula

C24H24N6O2

CAS

2226521-65-7

Smiles

CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N

Receptor (IC50)

JAK3: 127pM

Solubility

DMSO: 15mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for FM381, inhibitor

Home; Angiogenesis; JAK

Product References and Citations for FM381, inhibitor

1. Forster M, et al. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol. 2016 Nov 17;23 (11):1335-1340.

Other Notes

Small volumes of FM381, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FM381 purchase

MBS5751553 is an inhibitor targeting FM381.