SRT1720 Inhibitor – SRT 1720

Name: SRT1720 Inhibitor; SRT 1720; MyBioSource
Brand: MyBioSource
SKU: MBS5751558
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751558

SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16uM) and is >230-fold less potent for SIRT2 and SIRT3. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SRT 1720 (SRT1720), Inhibitor

Full Product Name

SRT 1720

Product Gene Name

SRT1720, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

469.56

Formula

C25H23N7OS

CAS

925434-55-5

Smiles

O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1

Receptor (IC50)

SIRT1: 0.16uM (EC1.5, cell free)
SIRT2: 37uM (EC1.5, cell free)

Solubility

DMSO: 60mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for SRT1720, inhibitor

Home; Chromatin/Epigenetic; Sirtuin

Product References and Citations for SRT1720, inhibitor

1. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450 (7170):712-6
2. Chauhan D, et al. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br J Haematol. 2011 Dec;155 (5):588-98.
3. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122 (6):2032-45.
4. Yu L, et al. Protective effects of SRT1720 via the HNF1alpha/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11.

Other Notes

Small volumes of SRT1720, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRT1720 purchase

MBS5751558 is an inhibitor targeting SRT1720. Also known as SRT 1720.