Avapritinib Inhibitor

Name: Avapritinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751569
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751569

Avapritinib is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27nM) and PDGFRalpha (PDGFRalpha D842V, IC50: 0.24nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Avapritinib, Inhibitor

Full Product Name

Avapritinib

Product Synonym Names

BLU-285

Form/Format

Powder

Purity/Purification

96.59%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

498.56

Formula

C26H27FN10

CAS

1703793-34-3

Smiles

Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1

Receptor (IC50)

KIT D816V: 0.27nM
PDGFRalpha D842V: 0.24nM

Solubility

DMSO: 65mg/mL
Water: Insoluble
Ethanol: 3mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Avapritinib, inhibitor

Home; Angiogenesis; PDGFR

Product References and Citations for Avapritinib, inhibitor

1. Erica Evans, et al. Blu-285, a Potent and Selective Inhibitor for Hematologic Malignancies with KIT Exon 17 Mutations.Blood 2015 126:568.
2. Evans EK, et al. A precision therapy against cancers driven by KIT/PDGFRA mutations. Sci Transl Med. 2017 Nov 1;9 (414). pii: eaao1690.

Other Notes

Small volumes of Avapritinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Avapritinib purchase

MBS5751569 is an inhibitor targeting Avapritinib.