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GDC-0810 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751572

MBS5751572 is an inhibitor targeting GDC-0810. GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GDC-0810, Inhibitor
Full Product Name
GDC-0810
Product Gene Name
GDC-0810, inhibitor
Product Synonym Names
GDC0810; GDC 0810; ARN-810; Brilanestrant; RG 6046
Form/Format
Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
446.9
Formula
C26H20ClFN2O2
CAS
1365888-06-7
Smiles
CC\C(=C(\c1ccc(\C=C\C(O)=O)cc1)c1ccc2[nH]ncc2c1)c1ccc(F)cc1Cl
Receptor (IC50)
Eralpha: 0.7nM
Solubility
DMSO: 30mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GDC-0810, inhibitor

Home; Endocrinology/Hormones; Estrogen/progestogen Receptor

Structure of GDC-0810, inhibitor

GDC-0810 Inhibitor – Cat# MBS5751572

Product References and Citations for GDC-0810, inhibitor

1. By Lai, et al. Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. J Med Chem. 2015 Jun 25;58 (12):4888-904.
2. Joseph JD, et al. The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Elife. 2016 Jul 13;5. pii: e15828. doi: 10.7554/eLife.15828.

Other Notes

Small volumes of GDC-0810, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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