dBET6 Inhibitor

Name: dBET6 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751583
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751583

dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14nM). It has antitumor activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

dBET6, Inhibitor

Full Product Name

dBET6

Product Gene Name

dBET6, inhibitor

Form/Format

Powder

Purity/Purification

98.76%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

841.37

Formula

C42H45ClN8O7S

CAS

1950634-92-0

Smiles

Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1

Receptor (IC50)

BET: 14nM

Solubility

DMSO: 10mM
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for dBET6, inhibitor

Home; Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for dBET6, inhibitor

1. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67 (1):5-18.e19.

Other Notes

Small volumes of dBET6, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for dBET6 purchase

MBS5751583 is an inhibitor targeting dBET6.