MKT-077 Inhibitor

Name: MKT-077 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751599
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751599

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2uM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MKT-077, Inhibitor

Full Product Name

MKT-077

Product Gene Name

MKT-077, inhibitor

Product Synonym Names

MKT077; MKT 077; FJ-776

Form/Format

Powder

Purity/Purification

97.90%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

432

Formula

C21H22ClN3OS2

CAS

147366-41-4

Smiles

[Cl-].CCn1c(=Cc2cccc[n+]2CC)s\c(=C2\Sc3ccccc3N2C)c1=O

Receptor (IC50)

HSP70

Solubility

DMSO: 20mg/mL
Water: 20mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for MKT-077, inhibitor

Home; Cytoskeletal Signaling; HSP

Product References and Citations for MKT-077, inhibitor

1. Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30 (4):593-603.
2. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4 (11).
3. Weisberg EL, et al. In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function. Cancer Res. 1996 Feb 1;56 (3):551-5.

Other Notes

Small volumes of MKT-077, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MKT-077 purchase

MBS5751599 is an inhibitor targeting MKT-077.