Apatinib mesylate Inhibitor

Name: Apatinib mesylate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751600
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751600

Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1nM). In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Apatinib mesylate, Inhibitor

Full Product Name

Apatinib mesylate

Product Synonym Names

Apatinib; YN968D1

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

493.57

Formula

C25H27N5O4S

CAS

1218779-75-9

Smiles

CS(O)(=O)=O.O=C(Nc1ccc(cc1)C1(CCCC1)C#N)c1cccnc1NCc1ccncc1

Receptor (IC50)

VEGFR2: 1nM (Cell-free)
RET: 13nM (Cell-free)

Solubility

DMSO: 25mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Apatinib mesylate, inhibitor

Home; Angiogenesis; VEGFR

Product References and Citations for Apatinib mesylate, inhibitor

1. Tian S, et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102 (7):1374-80.
2. Mi YJ, et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010 Oct 15;70 (20):7981-91.

Other Notes

Small volumes of Apatinib mesylate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Apatinib mesylate purchase

MBS5751600 is an inhibitor targeting Apatinib mesylate.