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Leniolisib Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751611

MBS5751611 is an inhibitor targeting Leniolisib. Leniolisib (CDZ173) is a potent and selective PI3Kdelta inhibitor (IC50: 11nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Leniolisib, Inhibitor
Full Product Name
Leniolisib
Product Synonym Names
CDZ173
Form/Format
Powder
Purity/Purification
99.97%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
450.46
Formula
C21H25F3N6O2
CAS
1354690-24-6
Smiles
CCC(=O)N1CC[C@@H](C1)Nc1ncnc2CCN(Cc12)c1cnc(OC)c(c1)C(F)(F)F
Receptor (IC50)
PI3Kdelta: 11nM (cell free)
PI3Kalpha: 280nM (cell free)
PI3Kbeta: 480nM (cell free)
DNA-PK: 880nM (cell free)
Solubility
DMSO: 85mg/mL
Ethanol: 10mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Leniolisib, inhibitor

Home; PI3K/Akt/mTOR signaling; PI3K

Structure of Leniolisib, inhibitor

Leniolisib Inhibitor – Cat# MBS5751611

Product References and Citations for Leniolisib, inhibitor

1. Hoegenauer K, et al. Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 25;8 (9):975-980.
2. Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 20028-4793; 1533-4406

Other Notes

Small volumes of Leniolisib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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