AZ876 Inhibitor

Name: AZ876 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751623
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751623

AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6nM and 11/73nM for hLXRalpha and hLXRbeta respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ876, Inhibitor

Full Product Name

AZ876

Product Gene Name

AZ876, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

439.57

Formula

C24H29N3O3S

CAS

898800-26-5

Smiles

CC(C)(C)N1C(=O)C(Nc2ccc(cc2)N2CCCCC2)=C(c2ccccc2)S1(=O)=O

Receptor (IC50)

LXR: 6nM (EC50, cell free)

Solubility

DMSO: 2.5mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for AZ876, inhibitor

Home; Others

Product References and Citations for AZ876, inhibitor

1. van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162 (7):1553-63.
2. Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17 (3):273-82.

Other Notes

Small volumes of AZ876, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ876 purchase

MBS5751623 is an inhibitor targeting AZ876.