GS-444217 Inhibitor

Name: GS-444217 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751634
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751634

GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GS-444217, Inhibitor

Full Product Name

GS-444217

Product Gene Name

GS-444217, inhibitor

Product Synonym Names

GS444217; GS 444217

Form/Format

Powder

Purity/Purification

99.58%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

411.46

Formula

C23H21N7O

CAS

1262041-49-5

Smiles

O=C(Nc1cccc(c1)-c1nncn1C1CC1)c1cc(ccn1)-n1cnc(c1)C1CC1

Receptor (IC50)

ASK1: 2.87nM (cell free)

Solubility

DMSO: 13mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GS-444217, inhibitor

Home; Apoptosis; ASK

Product References and Citations for GS-444217, inhibitor

2. Tesch GH, et al. ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice. Diabetes. 2015 Nov;64 (11):3903-13.
3. Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128 (10):4485-4500.
4. Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197 (3):373-385.

Other Notes

Small volumes of GS-444217, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GS-444217 purchase

MBS5751634 is an inhibitor targeting GS-444217.