Danirixin Inhibitor

Name: Danirixin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751637
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751637

Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Danirixin, Inhibitor

Full Product Name

Danirixin

Product Synonym Names

GSK1325756

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

441.9

Formula

C19H21ClFN3O4S

CAS

954126-98-8

Smiles

Cc1c(F)cccc1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@H]1CCCNC1

Receptor (IC50)

CXCL8-CXCR2: 12.5nM (cell free)

Solubility

DMSO: 8mg/mL (18.10mM), Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Danirixin, inhibitor

Home; Autophagy; CXCR; Danirixin

Product References and Citations for Danirixin, inhibitor

1. Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
2. Miller BE, et al. The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers. Eur J Drug Metab Pharmacokinet. 2014 Sep;39 (3):173-81.

Other Notes

Small volumes of Danirixin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Danirixin purchase

MBS5751637 is an inhibitor targeting Danirixin.